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Biomarkers related ...
Biomarkers related to one-carbon metabolism as potential risk factors for distal colorectal adenomas
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de Vogel, Stefan (author)
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- Schneede, Jörn (author)
- Umeå universitet,Klinisk farmakologi
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Ueland, Per Magne (author)
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Vollset, Stein Emil (author)
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Meyer, Klaus (author)
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Fredriksen, Åse (author)
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Midttun, Øivind (author)
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Bjørge, Tone (author)
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Kampman, Ellen (author)
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Bretthauer, Michael (author)
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Hoff, Geir (author)
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(creator_code:org_t)
- American Association for Cancer Research, 2011
- 2011
- English.
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In: Cancer Epidemiology, Biomarkers and Prevention. - : American Association for Cancer Research. - 1055-9965 .- 1538-7755. ; 20:8, s. 1726-1735
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND: Efficient one-carbon metabolism, which requires adequate supply of methyl group donors and B-vitamins, may protect against colorectal carcinogenesis. However, plasma folate and vitamins B2 and B12 have inconsistently been associated with colorectal cancer risk, and there have been no previous studies relating plasma concentrations of methionine, choline, and betaine to this outcome.METHODS: This study comprised 10,601 individuals, 50 to 64 years of age, participating in the Norwegian Colorectal Cancer Prevention (NORCCAP) screening study. Using logistic regression analyses, we crosssectionally investigated associations between distal colorectal adenoma occurrence-potential precursor lesions of colorectal carcinomas-and plasma concentrations of methyl group donors and B-vitamins, and polymorphisms of genes related to one-carbon metabolism.RESULTS: Screening revealed 1,809 subjects (17.1%) with at least one adenoma. The occurrence of high-risk adenomas (observed in 421 subjects) was inversely associated with plasma concentrations of methionine (highest versus lowest quartile: odds ratio (OR) = 0.61; 95% confidence interval (CI) = 0.45-0.83), betaine: OR = 0.74; 95% CI = 0.54-1.02, the vitamin B2 form flavin-mononucleotide (FMN): OR = 0.65; 95% CI = 0.49-0.88, and the vitamin B6 form pyridoxal 5'-phosphate (PLP): OR = 0.69; 95% CI = 0.51-0.95, but not with folate, choline, vitamin B12 concentrations, or with the studied polymorphisms. High methionine concentration in combination with high vitamin B2 or B6 concentrations was associated with lower occurrence of high-risk adenomas compared with these factors individually.CONCLUSIONS: High plasma concentrations of methionine and betaine, and vitamins B2 and B6 may reduce risk of developing colorectal adenomas.IMPACT: In addition to B-vitamins, methyl group donors such as methionine and betaine may play a role in colorectal carcinogenesis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Keyword
- nested case-control
- methylenetetrahydrofolate reductase polymorphism
- island methylator phenotype
- tandem mass-spectrometry
- cancer risk
- plasma folate
- B-vitamins
- microbiological assay
- genetic polymorphisms
- asymptomatic adults
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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de Vogel, Stefan
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Schneede, Jörn
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Ueland, Per Magn ...
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Vollset, Stein E ...
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Meyer, Klaus
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Fredriksen, Åse
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show more...
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Midttun, Øivind
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Bjørge, Tone
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Kampman, Ellen
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Bretthauer, Mich ...
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Hoff, Geir
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Occupational Hea ...
- Articles in the publication
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Cancer Epidemiol ...
- By the university
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Umeå University